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Descriptor English: Retinoblastoma-Like Protein p107
Descriptor Spanish: Proteína p107 Similar a la del Retinoblastoma
Descriptor proteína p107 similar a la del retinoblastoma
Entry term(s) proteína 1 similar a la del retinoblastoma
proteína RBL1
Scope note: Regulador negativo del CICLO CELULAR que sufre FOSFORILACIÓN por las CINASAS DEPENDIENTES DE LA CLICLINA. Contiene una región pocket conservada que se une al FACTOR DE TRANSCRIPCIÓN E2F4 e interactúa con ONCOPROTEÍNAS víricas como los ANTÍGENOS TUMORALES DEL PAPILOMAVIRUS, las PROTEÍNAS E1A DEL ADENOVIRUS y las PROTEÍNAS E7 DEL PAPILOMAVIRUS.
Descriptor Portuguese: Proteína p107 Retinoblastoma-Like
Descriptor French: Protéine p107 de type rétinoblastome
Entry term(s): RBL1 Protein
Retinoblastoma Like Protein 1
Retinoblastoma Like Protein p107
Retinoblastoma-Like Protein 1
p107 Tumor Suppressor Protein
p107, Retinoblastoma-Like Protein
Tree number(s): D12.776.624.776.717
D12.776.660.770
D12.776.744.747
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D050720
Scope note: A negative regulator of the CELL CYCLE that undergoes PHOSPHORYLATION by CYCLIN-DEPENDENT KINASES. It contains a conserved pocket region that binds E2F4 TRANSCRIPTION FACTOR and interacts with viral ONCOPROTEINS such as POLYOMAVIRUS TUMOR ANTIGENS; ADENOVIRUS E1A PROTEINS; and PAPILLOMAVIRUS E7 PROTEINS.
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Public MeSH Note: 2006; RETINOBLASTOMA-LIKE PROTEIN P107 was indexed under NUCLEAR PROTEINS 1995-2005 & under PROTEINS 1991-1994
History Note: 2006(1991)
DeCS ID: 51162
Unique ID: D050720
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 2006/01/01
Date of Entry: 2005/06/30
Revision Date: 2009/07/06
Retinoblastoma-Like Protein p107 - Preferred
Concept UI M0477276
Scope note A negative regulator of the CELL CYCLE that undergoes PHOSPHORYLATION by CYCLIN-DEPENDENT KINASES. It contains a conserved pocket region that binds E2F4 TRANSCRIPTION FACTOR and interacts with viral ONCOPROTEINS such as POLYOMAVIRUS TUMOR ANTIGENS; ADENOVIRUS E1A PROTEINS; and PAPILLOMAVIRUS E7 PROTEINS.
Preferred term Retinoblastoma-Like Protein p107
Entry term(s) RBL1 Protein
Retinoblastoma Like Protein 1
Retinoblastoma Like Protein p107
Retinoblastoma-Like Protein 1
p107 Tumor Suppressor Protein
p107, Retinoblastoma-Like Protein



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